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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T13177L | Tocainide | Sodium Channel | |
Tocainide is a blocker of the sodium channel and used for the treatment of tinnitus. | |||
T4S1876 | 3-Deoxyaconitine | Sodium Channel | |
3- Deoxyaconitine is a derivative of Aconitine (A189875), which activates tetrodotoxin-sensitive Na+ channels, inducing presynaptic depolarization, thus blocking the nerve action potential which, in turn, blocks the rele... | |||
T5850 | Benzamil | Benzamil (hydrochloride) | Na+/Ca2+ Exchanger , Sodium Channel |
Benzamil is an epithelial sodium channel (ENaC) blocker that inhibits sodium transport from (IC50 = 4 nM) and binds to (Kd = 5 nM) bovine kidney cortex membrane vesicles. | |||
T4490 | PF-01247324 | Sodium Channel | |
PF-01247324 is a selective and orally bioavailable Nav1.8 channel blocker (IC50: 196 nM). | |||
T12786 | RY785 | Potassium Channel | |
RY785 is a potent and selective inhibitor of voltage-gated potassium channel such as KV2.2 (IC50 = 50 nM). RY785 may be used in pain relief studies. | |||
T16514 | PF 04531083 | Others , Sodium Channel | |
PF 04531083 is a selective blocker of the NaV1.8 channel. PF 04531083 can be used for neuropathic and inflammatory pain studies. | |||
TQ0011 | PF-06869206 | Sodium Channel | |
PF-06869206 is an oral selective inhibitor of the sodium-phosphate cotransporter NaPi2a (SLC34A1, IC50: 380 nM). | |||
T15174 | DSP-2230 | Sodium Channel | |
DSP-2230 is a selective blocker of Nav1.7/Nav1.8. | |||
T5324 | BI 01383298 | Sodium Channel | |
BI 01383298 is a selective inhibitor of the sodium-citrate co-transporter (SLC13A5). | |||
TQ0014 | GNE-131 | Sodium Channel | |
GNE-131 is a potent and specific inhibitor of human sodium channel NaV1.7 (IC50: 3 nM). | |||
T37688 | Cyfluthrin | Reactive Oxygen Species , Sodium Channel | |
Cyfluthrin binds to voltage-sensitive sodium channel such as Nav 1.8 sodium channel and modify their gating kinetics, thereby disrupting nerve function of pests. | |||
T23070 | Nisoxetine hydrochloride | Sodium Channel , Monoamine Transporter , Norepinephrine | |
Nisoxetine hydrochloride is a noradrenaline transporter (NET) inhibitor | |||
T19644 | Benzonatate | Sodium Channel | |
Benzonatate is an antagonist of sodium channel protein. | |||
T8581 | Flecainide hydrochloride | Others | |
Flecainide is a medication used to prevent and treat abnormally fast heart rates. This includes ventricular and supraventricular tachycardias. | |||
T0924 | Benzocaine | Others , MRP , Sodium Channel | |
Benzocaine is a surface anesthetic that acts by preventing transmission of impulses along nerve fibers and at nerve endings. | |||
T9683 | VX-150 | Sodium Channel | |
VX-150 is a highly selective NaV1.8 inhibitor relative to the other sodium channel subtypes (>400-fold). | |||
T1787 | Levobupivacaine | Sodium Channel | |
Levobupivacaine is an amino-amide local anaesthetic drug belonging to the family of n-alkylsubstituted pipecoloxylidide. It is the S-enantiomer of bupivacaine. Levobupivacaine hydrochloride is commonly marketed by AstraZ... | |||
T9685 | DS-1971a | Sodium Channel | |
DS-1971a is a highly potent and selective NaV1.7 inhibitor. DS-1971a exhibits a favorable toxicological profile and analgesic effects. | |||
T0364 | Dibucaine | Cinchocaine | CaMK , Sodium Channel , AChR |
Dibucaine (Cinchocaine), a local anesthetic of the amide type, is now usually used for surface anesthesia. | |||
T12181 | NaV1.7 inhibitor-1 | Sodium Channel | |
NaV1.7 inhibitor-1, an efficacious inhibitor of voltage-gated sodium channel (NaV) 1.7 (IC50 of 0.6 nM for hNaV1.7). |